The encounter will take place in Bucharest instead of Madrid due to coronavirus travel restrictions.
Tuchel has guided Chelsea to five wins out of seven in all competitions since replacing Frank Lampard last month.
“We just have to make a good game against a very big team, with a new coach, a very big coach and an important one that did his job everywhere he went to,” Simeone said.
“Chelsea is a very strong club, they develop every time and every year. They bring a lot of new players and invest in young players.
“When they didn’t see the investment and it didn’t pay, they had that change. They brought Tuchel but it is a really big team and since he came he put a good change in the numbers.
“Just look at what players they have at goalkeeper, at striker and everyone who is on the bench can very well play in any team in Europe.”
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