It was Rangers’ second consecutive defeat in the group.
The Flying Antelopes lost 3-1 to another Egyptian club, Pyramids FC last weekend
Rangers now face an uphil task in their bid to make it to the next round of the competition.
Nigeria forward Austin Amutu put Al Masry ahead in the fifth minute after he was set up by Muftah Taktak.
It was Amutu’s third goal of the competition for the club.
Ahmed Yasser netted the second goal in the 27th minute, while Taktak added the third three minutes after the break.
Hassan Ali made the scoreline more emphatic when he scored the home team fourth seven minutes from time.
Rangers however scored two late goals through Eziekwe Chinonso and own goal by Saidou Simpore to make the scoreline more respectable.
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