Lille, with a paltry one point from five games, are already out of the competition with no chance of also getting a place in the UEFA Europa League.
Osimhen scored Lille’s only goal in the 2-1 home defeat to Chelsea on matchday-two.
The Nigeria international has scored two goals in five appearances for Les Dogues in the competition this season.
At the Signal Iduna Park, Dortmund, Peter Olayinka and his Slavia Prague’s teammates will have the same mission as Osimhen at the back of their minds when they take on their hosts, Borussia Dortmund in a Group F encounter.
Slavia Prague have only pride to play for after garnering just two points from five games in the group.
Log leaders Barcelona with 11 points are already through to the next round, while Inter Milan and Dortmund who have seven points each are battling for the other spot in the group.
Olayinka, who earned plaudits for his performance in group games against Inter Milan and Barcelona has scored once in five games for Slavia Prague.
Also on Tuesday, the duo of Paul Onuachu and Steven Odey, and their KRC Genk teammates have only pride to play for in a Group E clash against Napoli at the Stadio San Paolo.
The Belgian champions have picked just one point from five group games.
Onuachu has featured four times for Genk in the competition with no goal to his name, while Odey scored in his only one appearance when the defending champions Liverpool beat the Felice Mazzu’s team 4-1 at the Luminus Arena on October 23.
On Wednesday, Emmanuel Dennis and David Okereke will hope to help Belgian club, Club Brugge secure a berth in the Europa League when they host Real Madrid in a Group A game at home.
Dennis scored both goals in Club Brugge’s 2-2 away draw at the Santiago Bernabeu on matchday-one. He has featured in all five group games for the club.
Okereke has featured four times in the competition this season.
Club Brugge , who have garnered three points from five games are battling with Turkish side, Galatasaray who have two points from the same number of games, for a place in the Europa League.
Galatasaray are away to Paris Saint Germain in France.
Also on Wednesday, Bryan Idowu is expected to be in action when his Russian club, Locomotiv Moscow face Atletico Madrid at the Wanda Metropolitan.
Locomotiv Moscow occupy bottom spot in the group with three points.