Osimhen scored with 10 minutes remaining from the penalty spot, to help Lille end a run of three straight defeats.
Adrien Thomasson had given Strasbourg the lead in the 12th minute before Gabriel Magalhaes equalised for Lille on 65 minutes.
Osimhen now has 11 goals in 21 league outings for Lille so far this season.
Lille are fourth on 34 points and occupy Europa League qualification spot.
In the Scottish Premier League, Super Eagles midfielder Joe Aribo was on for 90 minutes as Rangers were held to a 0-0 draw at home by Aberdeen.
Aribo made his 21st league appearance this season with two goals.
The draw saw Rangers miss the chance to close the gap on leaders Celtic in the race for the title.
Rangers remain second on 57 points just four points away from Celtic.
And in Turkey, former Super Eagles captain John Mikel Obi was in action for Trabzonspor in their 2-1 comeback win against visiting Fenerbahce.
Mike’s Nigerian teammate Anthony Nwakaeme was not in Trabzonspor’s squad for the game.
It was Mike’s 14th league appearance this season for Trabzonspor.
Max Kruse gave Fenerbahce the perfect start when he scored one minute into the game.
Alexander Sorloth equalised for Trabzonspor in the 15th minute before Filip Novak got the winner on 32 minutes.
Trabzonspor now occupy third spot on 38 points and are three points behind leaders Sivasspor.