Liverpool will host Everton in the third round of the FA Cup, while Championship leaders Leeds United will travel to Arsenal.
Holders Manchester City will welcome League Two side Port Vale and Manchester United go to Wolves in a repeat of last season’s quarter-final.
National League side AFC Fylde, the lowest ranked team definitely through to the third round, will travel to Premier League Sheffield United.
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Ties are played between 3-6 January.
Boston, of the sixth-tier National League North, will host Premier League opposition in Newcastle United, if they can come through a replay against Rochdale on Tuesday, 10 December.
Fellow non-league sides Hartlepool and Eastleigh also face replays, but could meet Oxford United and Barnsley respectively should they progress.