Osimhen put Lille ahead in the 51st minute following a beautiful pass from Jonathan Bamba.
The 21-year-old also has four assists in 24 league appearances for Les Dogues this season.
Valentin Roniger missed a penalty for Marseille on the hour mark.
Andre Villas-Boas’ men however rallied back through Reinildo’s own goal and a Dario Bennedeto strike.
Lille remain in fourth position despite the defeat with 40 points from 25 games.
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