Moffi set up Jerome Hergault for Lorient’s goal in the 23rd minute which made it 1-1.
But Lille went on to score three more goals to claim the big win away from home.
Prior to Sunday’s fixture Lorient had gone six consecutive games without defeat, winning four and drawing two.
They are now in 18th position (relegation play-off spot) on 23 points on the log.
Moffi has scored nine goals in 20 appearances in all competitions this season.
By James Agberebi
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