Iheanacho has scored two goals in three league appearances for Leicester City this season.
The Nigeria international failed to make the matchday squad for Thursday’s 4-0 home loss to Liverpool.
Rodgers knows he will have to field a different side from the team that lost to Liverpool with just a day to prepare for the game, but has confidence in the players that will line up against the Hammers.
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“Yes, just purely for the welfare of the players,” said Rodgers when asked whether he will make changes to his outfit.
“It’s when you see we put so much into tonight physically and we have a massive January coming up for us as a squad and as a team.
My fear is that we would be risking too many guys getting injured if we’re playing at 5:30pm on Saturday.
“Normally, in a day where your body is recovering, I’m going to need to make those changes.”