Solskjaer make seven changes to the side that played a 1-1 draw in the first leg of the Round of 32 fixture last week.
Ighalo, who joined the Red Devils on a loan in January from Chinese club, Shanghai Shenhua will be looking to score his first goal for the club.
Bruno Fernandes also gets the nod for Manchester United in the No. 10 role, after featuring as a substitute in the first leg in Belgium.
The Portuguese playmaker is flanked by Daniel James and Juan Mata, with Mason Greenwood, who started in the weekend win against Watford, dropping to the bench.
In midfield, Scott McTominay starts for the Red Devils , having marked his return from injury with a substitute appearance at the weekend. The academy graduate is partnered by the in-form Fred in the double pivot, with Nemanja Matic benched.
Aaron Wan-Bissaka and Luke Shaw have been retained in the full-back slots by Solskjaer while Manchester United captain Harry Maguire keeps his place in defence.
Eric Bailly, who has not featured since making his comeback from injury against Chelsea, comes into the side though at the expense of Victor Lindelof. Sergio Romero starts in goal ahead of David de Gea.
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