It was Eze’s first goal since new year’s day 6-1 home win against Cardiff while it was also Osayi-Samuel’s first since 5th January.
Prior to Saturday’s game both Eze and Osayi-Samuel went seven games without scoring.
Eze now has 11 goals in 33 league games while Osayi-Samuel has scored five goals in 25 games.
The win saw QPR end their run of five straight games without victory.
Sam Clucas had opened scoring for Stoke in the 27th minute before Tyrese Campbell doubled their lead on 31 minutes.
Jordan Hugill pulled a goal back for QPR to make it 2-1 in 34th with Eze completing the comeback on 38 minutes.
In the 71st minute Osayi-Samuel put QPR 3-2 ahead before Ilias Chair added the fourth goal on 91 minutes.
QPR are now in 16th position on 42 points in the 24-team league table.
Also on Saturday, Super Eagles defender Semi Ajayi featured for West Bromwich Albion who were forced to a 2-2 draw at home by Nottingham Forest.
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