Karim El Berkaoui opened scoring for the home team in the 14th minute, while Senegalese forward Malick Cisse added the second five minutes later.
Enyimba battled hard to get back into the game but were unable to breach the hosts’ defence.
In the other Group D game, San Pedro of Cote d’l voire were held to a 0-0 at home by Algerian club, Paradou A.C..
Enyimba will host San Pedro in Aba next week Sunday in a matchday-two encounter.
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