Manchester City raced into a 3-0 lead before the break, largely down to a De Bruyne masterclass.
De Bruyne put City ahead with a brilliantly controlled rebounded half volley in the 2nd minute before squaring for Raheem Sterling to double their lead in the 15th minute.
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De Bruyne made it three with a low curling effort from 20 yards five minutes before the break, then saw another bending long-range shot hit the post via Bernd Leno’s superb stop.
It was another of those days for Arsenal, who looked overawed throughout, while Mesut Ozil took criticism from the home fans as he walked slowly off the pitch when substituted at 3-0, prompting him to kick away his gloves in frustration.
The result leaves Manchester City 14 points behind leaders Liverpool, but now four points from Leicester after their slip against Norwich on Saturday, while Arsenal sit ninth, seven points off the top four.
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